Table 1 Physicochemical characterization of nanomicelles formulation
Formulation | Particle diameter (nm ± SD) | Zeta-potential (mV) ± SD | PDIa ± SD | EEb% of DTX |
|---|---|---|---|---|
DTX-PM | 38.5 ± 4.2 | − 2.15 ± 0.13 | 0.48 ± 0.17 | 81.2 ± 3.1 |
DOX-Hyd-PM | 45.6 ± 0.4 | − 19.2 ± 0.46 | 0.3 ± 0.28 | – |
DOX-Hyd-PM/DTX (1:1) | 69.9 ± 3.7 | − 15.67 ± 0.41 | 0.3 ± 0.15 | 76 |
DOX-Hyd-PM/DTX (1:5) | 122.6 ± 2.5 | − 16.7 ± 0.41 | 0.38 ± 0.1 | 56 |
Blank micelles | 15.3 ± 3.9 | − 2.54 ± 0.66 | 0.3 ± 0.048 | – |